Careers. They described a patient developing pityriasis rosea (PR) 2 hours after the second dose of Moderna COVID-19 vaccination. PMC This site needs JavaScript to work properly. Epub 2021 Aug 7. 8600 Rockville Pike -, Busto-Leis J.M., Servera-Negre G., Mayor-Ibarguren A., et al. PMC Human herpesviruses 6 and 7 are common. Bookshelf Cutis. Central dusky-red erythematous on some plaques (A); almost all lesions fading with associated post-inflammatory hyperpigmentation after treatment (B). National Library of Medicine Mohta A, Mohta A, Ghiya BC, Mehta RD, Kumar V. Indian J Dermatol. Would you like email updates of new search results? eCollection 2022 Jul. 2022 Sep;21(9):3692-3703. doi: 10.1111/jocd.15209. PS conceptualized the case report and revised the manuscript. See this image and copyright information in PMC. Several vaccines have been created to counteract the morbidity and mortality associated with COVID19 and stop viral transmission, including the Moderna vaccine (Mrna1273).The mRNA1273 vaccine is a lipid nanoparticle-encapsulated mRNAbased vaccine that encodes the prefusion stabilized fulllength spike . This site needs JavaScript to work properly. Adya KA, Inamadar AC, Albadri W. Post Covid-19 vaccination papulovesicular pityriasis rosea-like eruption in a young male. government site. Although the exact pathophysiologic mechanisms of PR after vaccination remain unclear, immune responses to COVID-19 vaccines and disruption of T-cell mediated control of latent infections were implicated (12, 1518). It is also called Christmas tree rash. Pityriasis rosea developing after COVID-19 vaccination. But some patients also are developing delayed skin reactions on. Ehsani AH, Nasimi M, Bigdelo Z. Pityriasis rosea as a cutaneous manifestation of COVID-19 infection. In addition to COVID-19 vaccination, she was currently taking medications (i.e., levetiracetam and thyroxin) for glioblastoma, and the two drugs had been prescribed for approximately nine months. -, Broccolo F., Drago F., Careddu A.M., et al. HHS Vulnerability Disclosure, Help Vaccinations have been identified to rarely cause several cutaneous reactions. 1. Epub 2021 May 29. It then causes many more small patches. Herald patch is often absent. It is important for physicians to be aware of this self-limited reaction so they can reassure and appropriately counsel patients that it is safe to receive subsequent vaccine doses despite the cutaneous eruption. An official website of the United States government. Once a person has pityriasis rosea, it rarely recurs. 2021 Aug;185(2):e34. Before Copyright 2021 Leerunyakul, Pakornphadungsit and Suchonwanit. Before PMC The length of the rash is shorter in comparison with PR.19. COVID-19; HHV, human herpes virus; Moderna; PR; PR, pityriasis rosea; PR-LE; PR-LE, pityriasis rosea-like eruption; Pfizer; coronavirus; dermatology; mRNA vaccine; mRNA, messenger RNA; pityriasis rosea; pityriasis rosealike eruption; vaccine. doi: 10.1111/dth.15602. PRISMA, preferred reporting. Before Unauthorized use of these marks is strictly prohibited. In one small study, a majority of women who got pityriasis rosea in . The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). The https:// ensures that you are connecting to the Br J Dermatol. Federal government websites often end in .gov or .mil. (2021) 85:4655. Numerous scattered erythematous plaques with fine scale oriented along skin cleavage lines, most appreciable on the upper portion of the chest. 2022 Jul 6;15(1):9503. doi: 10.4081/dr.2022.9503. Epub 2022 Feb 9. The https:// ensures that you are connecting to the Dermoscopy showed dotted and linear vessels forming a network on a yellowish background, with some whitish peripheral scales (Figure 3A). (2020) 33:e13878. Unable to load your collection due to an error, Unable to load your delegates due to an error. Careers. However, the etiopathogenetic mechanisms remain largely unknown and further studies are needed in order to clarify the correlation between SARS-CoV-2 and PR. (A) Dermoscopic features: dotted and linear vessels forming a network on a yellowish background with some whitish peripheral scales (original magnification x20). An official website of the United States government. National Library of Medicine Globally, as of 7:26 pm CEST, 10 October 2022, there have been 618,521,620 confirmed cases of COVID-19, including 6,534,725 deaths, reported to the WHO. It starts with one large round or oval scaly patch. Clinical manifestations and histopathologic findings of reported patients with pityriasis-rosea like eruptions following COVID-19 vaccination. FOIA The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. The authors declare no conflict of interest. 2021;85(1):4655. A 46-year-old man presented to our Department with a two-week history of skin rash associated with mild pruritus. Patient n. 1. Pityriasis rosea is a common self-limiting rash that usually starts with a herald patch on the trunk and progresses along the Langer lines to a generalized rash over the trunk and limbs. Drago F, Ciccarese G, Javor S, Parodi A. Vaccine-induced pityriasis rosea and pityriasis rosea-like eruptions: a review of the literature. Pityriasis rosea after mRNA COVID-19 vaccination. In 3 patients a biopsy for histopathological examinations was carried out. Dermatol Reports. Pityriasis rosea-like eruptions following vaccination with BNT162b2 mRNA COVID-19 Vaccine. An official website of the United States government. Future studies should investigate oral lesions in SARS-CoV-2-positive subjects and after COVID-19 vaccination in the pediatric population, taking into account viral variants and newly developed vaccines. Epub 2021 Apr 7. SPSS statistical software version 25 was used for appropriate inferential statistics. official website and that any information you provide is encrypted No HHV-6 and HHV-7 reactivation is detected. Variable dermatological manifestations including acral erythema, urticaria, vasculitis, vesicular or pustular eruptions, maculopapular rash have all been reported during the course of COVID19. government site. It is possible that a relationship anti- Sars-CoV-2 vaccinationPR/PRLE exists; however, it is very rare, in consideration of millions of vaccinated subjects and the low number of reported cases with PR/PRLE. Other plausible theories include molecular mimicry with viral epitopes and type IV delayed hypersensitivity reaction (12). J Eur Acad Dermatol Venereol. Published by Elsevier Inc. Pityriasis rosea. A 3-cm oval plaque with peripheral scale, larger than the other lesions, was present on the inferior portion of the right breast. Epub 2021 Apr 26. 8600 Rockville Pike Herald patch of pityriasis rosea. Department of Pathophysiology and Transplantation, Universit degli Studi, Foundation IRCCS Ca Granda Ospedale Maggiore Policlinico, Via Pace 9, 20122 Milan, Italy. Cases of pityriasis rosea/pityriasis rosea-like eruption after anti-SARS-CoV-2 vaccination reported in the literature. Gianotti-Crosti Syndrome is a rare skin disease affecting children at the first years of age. Here, we report the first case of PR-like eruption following ChAdOx1 nCoV-19 (Oxford/AstraZeneca) vaccination. Among patients who received COVID-19 vaccines, PR-like eruptions have been reported following the first (n = 1) or second dose (n = 2) of BNT162b2 mRNA-based vaccines (3, 4). Would you like email updates of new search results? (a) Pityriasis rosea (chest, flank, and axilla); (b) pityriasis rosea (back). SV, supervised the work. eCollection 2023 Mar 7. Before Unable to load your collection due to an error, Unable to load your delegates due to an error. Umakanthan S, Sahu P, Ranade AV, et al. (2017) 9:7399. doi: 10.4081/dr.2017.7399, 17. The https:// ensures that you are connecting to the KL and KP collated resources. Accessed February 2, 2022. Unable to load your collection due to an error, Unable to load your delegates due to an error. doi: 10.1159/000517971. Reply to "the significance of investigating clinical, histopathologic and virological features in pityriasis rosea and pityriasis rosea-like eruptions following COVID-19 vaccinations" by Ciccarese G. et al. Careers, Unable to load your collection due to an error. Drug-induced PR-like eruption accounts for 2% of all cutaneous adverse drug reactions (10). Clipboard, Search History, and several other advanced features are temporarily unavailable. Would you like email updates of new search results? Scleroderma or CREST syndrome is a chronic, auto immune disease which manifests as. It has been reported that pityriasis rosea has been triggered by several vaccines, as a rare side-effect. In some cases, central hyperpigmentation was identified. Nicotinamide does not prevent skin cancer in solid organ transplant recipients (March 2023) URTICARIA AND ANGIOEDEMA. See this image and copyright information in PMC. J Med Virol 2021; 93: 1850-1851. Histopathologic examination revealed epidermal focal spongiosis, interface dermatitis with necrotic keratinocytes, perivascular lymphocytic infiltration, and few eosinophilic infiltrations in the superficial dermis (Figures 3B,C). 18. COVID-19 has been reported as one such viral trigger for PR. However, in cases of atypical PR, it may present with erythema multiforme-like lesions and purpura (5). Drago F, Ciccarese G, Parodi A. Pityriasis rosea and pityriasis rosea-like eruptions: How to distinguish them? Informed consent: Informed consent has been obtained. (2021) 93:18501. Mohta A, Nyati A, Mohta A, Ghiya BC, Mehta RD, Kumar V. Indian Dermatol Online J. PR is a common self-limited papulosquamous eruption typically presenting with a large solitary pink-colored patch or plaque (i.e., herald patch), followed by secondary eruptions of smaller erythematous patches or plaques with associated peripheral collarette scaling distributed along the cleavage lines of the trunk, forming a Christmas tree pattern (5). HHS Vulnerability Disclosure, Help JAAD Int. Would you like email updates of new search results? Ethical review and approval was not required for the study on human participants in accordance with the local legislation and institutional requirements. National Library of Medicine Pityriasis rosea (PR)-like eruption is a cutaneous complication associated with several medications and vaccinations. Epub 2022 Feb 9. This site needs JavaScript to work properly. Epub 2021 Jun 28. This table includes information on vaccines that have published phase 3 trial data in the peer reviewed literature and are provisionally approved by the Australian Government Therapeutic Goods Administration (TGA). Unauthorized use of these marks is strictly prohibited. Dermatology. 8600 Rockville Pike Vaccine-induced pityriasis rosea and pityriasis rosea-like eruptions: a review of the literature. But there are important differences between these 2 conditions. Pityriasis Rosea Induced by COVID-19 Vaccination Eur J Case Rep Intern Med. 2022 Nov 6;15:2369-2382. doi: 10.2147/CCID.S388245. 2021;35(8):e489e491. Pityriasis rosea (PR)-like eruption is a cutaneous complication associated with several medications and vaccinations. Before Dursun R, Temiz SA. KL drafted the original manuscript. 2022 Jul 6;15(1):9503. doi: 10.4081/dr.2022.9503. Pityriasis rosea following SARS-CoV-2 vaccination: A case series. J Eur Acad Dermatol Venereol 2020; 34: e436-e437. Unauthorized use of these marks is strictly prohibited. SARS-CoV-2 vaccine; cutaneous side-effects; infection; papulosquamous; skin diseases; vaccine hesitancy. A rash on the back of a Covid patient. Disclaimer. Clipboard, Search History, and several other advanced features are temporarily unavailable. -, Carballido Vzquez A.M., Morgado B. Pityriasis rosea-like eruption after Pfizer-BioNTech COVID-19 vaccination. Six days later, she developed a rash on her. Environ Sci Pollut Res. Post Covid-19 vaccination papulovesicular pityriasis rosea-like eruption in a young male. Accessibility The patients/participants provided their written informed consent to participate in this study. doi: 10.1111/jdv.12942, 13. Written informed consent was obtained from the individual(s) for the publication of any potentially identifiable images or data included in this article. Keywords: adverse effect, coronavirus, cutaneous eruptions, immunization, pityriasis rosea, SARS-CoV-2, vaccine, case report, Citation: Leerunyakul K, Pakornphadungsit K and Suchonwanit P (2021) Case Report: Pityriasis Rosea-Like Eruption Following COVID-19 Vaccination. J Eur Acad Dermatol Venereol. The SARSCoV2 pandemic plagued the world over the course of the year. Busto-Leis JM, Servera-Negre G, Mayor-Ibarguren A, et al.. Pityriasis rosea, COVID-19 and vaccination: new keys to understand an old acquaintance, Pityriasis rosea following CoronaVac COVID-19 vaccination: a case report, Pityriasis rosea after administration of Pfizer-BioNTech COVID-19 vaccine. Typically preceded by a primary solitary herald patch followed by the onset of smaller scaly papulo-squamous lesions on the skin tension lines within days to weeks.1 Reactivation of herpes virus 6 and 7 has been incriminated as a . Nevertheless, she did not present with fever or respiratory tract symptoms. The rash most often appears on the chest, back, and belly. Pityriasis Rosea Shortly After mRNA-1273 COVID-19 Vaccination. It is believed to represent a delayed reaction to viral infections and is usually associated with endogenous systemic reactivation of human herpesvirus (HHV) 6 and / or 7 (1). Manifestation of pityriasis rosea and pityriasis rosea-like eruptions after Covid-19 vaccine: A systematic review. HHS Vulnerability Disclosure, Help The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). [Epub ahead of print]. Treatment with topical 0.1% triamcinolone acetonide twice per day showed partial response after seven days. Chanprapaph K, Pomsoong C, Tankunakorn J, Eden C, Suchonwanit P, Rutnin S. Comparative analyses of clinical features, histopathology, and CD123 immunohistochemistry of oral lupus erythematosus, lichen planus, and other lichenoid lesions. These findings were consistent with a diagnosis of PR-like eruption. Curr Dermatol Rep. 2022;11(4):289-312. doi: 10.1007/s13671-022-00370-9. Laboratory investigation results (i.e., complete blood count, blood chemistry, C-reactive protein level, erythrocyte sedimentation rate, serological test for syphilis, plasma polymerase chain reaction (PCR) for human herpesvirus (HHV)-6 and HHV-7, and reverse transcription-PCR for COVID-19) were unremarkable. Conflict of interest: The authors declare no potential conflict of interest. Careers. See this image and copyright information in PMC. FOIA Epub 2022 Mar 8. Bethesda, MD 20894, Web Policies The advent of vaccines has drastically reduced the incidence, morbidity, and mortality related to COVID-19 [1]. doi: 10.1111/jdv.17342. +39.3465909404. 2022 Jun;7:164-168. doi: 10.1016/j.jdin.2022.01.009. Khan I, Elsanousi AA, Shareef AM, Tebha SS, Arif A, Gul S. Immun Inflamm Dis. (2017) 5:20311. NS, not specified; PR, pityriasis rosea; PRL, pityriasis rosea-like. To the best of our knowledge, there have been no reports of PR-like eruptions following inoculation with Oxford/AstraZeneca ChAdOx1 nCoV-19 (AZD1222) vaccine. 8600 Rockville Pike J Am Acad Dermatol. Pityriasis rosea is a common skin disease that is not contagious. JAAD Case Rep. 2021;7:9394. No report of Pityriasis rosea is found for people with Abdominal fullness prematurely after meals. Vaccination is one of the cornerstones in the efforts towards ending the coronavirus disease 2019 (COVID-19) pandemic. Hum Vaccin Immunother. PMC Martora F, Battista T, Marasca C, Genco L, Fabbrocini G, Potestio L. Clin Cosmet Investig Dermatol. Abdullah L, Hasbani D, Kurban M, Abbas O. Int J Dermatol. Although the exact pathogenesis of PR remains unknown, the endogenous systemic reactivation of HHV (i.e., type 6 and 7) in the skin has been implicated as a precipitating factor. Epub 2021 May 10. J Am Acad Dermatol. SV, CAM, MC, VB, collected the data. Before 2023 Mar 3;14(2):207-212. doi: 10.4103/idoj.idoj_449_22. (2015) 2015:253154. doi: 10.1155/2015/253154, 14. National Library of Medicine The condition is clinically featured by blisters on the skin of the legs, buttocks and arms. Moreover, central dusky-red erythematous was observed on some plaques (Figure 2A). The face may be involved; involvement of the oral cavity occurs in 50% of patients. J Eur Acad Dermatol Venereol. Keywords: Allergy Asthma Proc. PR is a self-limiting exanthematous disease and herpes zoster is a treatable condition; therefore, their occurrence does not require discontinuation of the vaccination schedule. The .gov means its official. eCollection 2021. See this image and copyright information in PMC. sharing sensitive information, make sure youre on a federal MeSH J Eur Acad Dermatol Venereol. J Eur Acad Dermatol Venereol 2016; 30: 544-545. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher. If so, the reason may be simple: in several countries, BNT162b2 is the most used vaccine; iii) in 55 cases the rash was classified as PR, in 6 cases as PRLE; iv) in 39 cases the eruption appeared 1-12 days after the first dose (around: 4.8 days). The .gov means its official. doi: 10.1111/dth.13650, 7. In 3 patients a biopsy for histopathological examinations was carried out. Despite this rare complication, our report highlights that the presence of PR-like eruption is not a contraindication for subsequent vaccinations. Clipboard, Search History, and several other advanced features are temporarily unavailable. Some studies have identified severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike proteins on endothelial cells and lymphocytes from PR-like lesions, consistent with direct viral invasion (3, 4). This site needs JavaScript to work properly. FOIA Numerous scattered erythematous plaques with fine scale oriented along skin cleavage, Herald patch of pityriasis rosea. The ones found in people with pityriasis rosea are human herpesviruses 6 and 7. The significance of investigating clinical, histopathologic and virological features in pityriasis rosea and pityriasis rosea-like eruptions following COVID-19 vaccinations. Cyrenne BM, Al-Mohammedi F, DeKoven JG, Alhusayen R. Pityriasis rosea-like eruptions following vaccination with BNT162b2 mRNA COVID-19 vaccine, Cutaneous adverse reactions after m- RNA COVID-19 vaccine: early reports from Northeast Italy. Perivascular lymphocytic infiltrates with some extravasated erythrocytes were observed in the superficial dermis (Figure 2). Drago F, Ciccarese G, Rebora A, Parodi A. Cutaneous reactions after COVID-19 vaccination in Turkey: A multicenter study. . 2023 Apr;11(4):e804. Accessibility Literature data about PR/PRLE after anti-SARS-CoV-2 vaccination may be summarized as follows: i) the infection occurs both in males and females (in several articles the gender was not reported); ii) the age ranges from 19 to 82 years (the count of the mean age is impossible because in several articles patients age was not specified).
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